Thursday, November 20, 2014
Research paper describes fundamental mechanistic aspects of widely used reaction
The University of Tulsa’s Grant Edwards (MS ’14) and biochemistry senior Phillip Culp, a Tulsa Undergraduate Research Challenge (TURC) scholar, recently published research on olefin metathesis in the journal Chemical Communications.
Olefin metathesis is a widely used reaction in organic synthesis. Edwards and Culp’s paper describes fundamental mechanistic aspects of the reaction and how to efficiently deploy it in organic synthesis. Their research centers on the allyl sulfide functional group, which directs the catalyst to react at a site of interest and increases the overall rate of the key reaction.
Under the guidance of Justin Chalker, assistant professor of chemistry and biochemistry, TU researchers are using their discoveries to streamline not only the synthesis of pharmaceutical compounds, but also covalently modified peptides and proteins.
The research paper “Allyl sulphides in olefin metathesis: catalyst considerations and traceless promotion of ring-closing metathesis” is available here.